Inside SIRE I.

Randomized human trial

A placebo-controlled trial enrolled 60 men with reduced sperm motility. After six months, the treated group showed improved sperm movement and higher semen CoQ10 levels; 55 men completed the study. A small, selected clinical population and semen endpoints do not establish a pregnancy benefit or the effects of SIRE I.

Before-and-after human study

In 50 men with abnormal sperm movement and shape, researchers reported improvements in count, movement and oxidative-stress markers after three months of NAC compared with participants’ own starting measurements. The reported methods compare participants with their own baseline, without a placebo comparison. This cannot isolate the effect of NAC or predict SIRE outcomes.

Randomized crossover trial

A double-blind crossover trial compared L-carnitine with placebo in selected men with infertility. The paper studied L-carnitine, not the finished SIRE formula. Its regimen should not be assumed equivalent to L-carnitine tartrate in this product.

Randomized pilot trial

A 90-day placebo-controlled pilot study enrolled 46 men with oligospermia and evaluated a specified root extract. This small pilot used a particular extract and regimen. Its findings cannot be transferred to an unverified extract or used to promise fertility outcomes.

Randomized human trial

A 12-week trial enrolled 60 healthy men. The primary measure, motile sperm concentration, did not change significantly; some secondary measures improved. Secondary findings do not override a non-significant primary endpoint. Healthy participants and lactolycopene are not equivalent to SIRE I or infertility treatment.

Large randomized trial

A multicenter trial of 2,370 couples found no significant improvement in live birth or most semen measures with folic acid plus zinc. The combination did not show the expected benefit and increased DNA fragmentation. It does not test zinc alone, zinc glycinate specifically or SIRE I.

Small randomized human trial

A three-month trial recruited 69 men. An improvement in motility was reported when the two selenium treatment groups were pooled; sperm density was unaffected. Small groups, pooled analysis and low baseline selenium status limit generalization. This does not establish benefit for well-nourished men or SIRE I.

Large randomized trial

The folic-acid-and-zinc trial enrolled 2,370 couples undergoing infertility treatment and found no significant live-birth benefit. The trial used folic acid with zinc and reported increased DNA fragmentation. It cannot isolate folate or be assumed to test SIRE’s final folate form.

Peer-reviewed biology review

This review examines B6-dependent biochemical reactions and the regulation of vitamin B6 within cells. A review of normal physiology is not a clinical fertility trial. It does not show that additional B6 improves conception or that SIRE I changes outcomes.

Peer-reviewed literature review

A review brought together clinical and experimental literature on B12 and semen quality, identifying a need for further clinical research. The evidence spans different study designs and populations. This review does not establish a fertility benefit from SIRE I or from supplementing people with adequate B12.

Randomized human trial

A double-blind placebo-controlled study reported no significant improvements in semen parameters or IVF outcomes between the treatment groups. This is a study of a specific vitamin E regimen, not SIRE I. Its negative findings are part of the evidence and should be considered alongside smaller positive studies.

Peer-reviewed biology review

This review examines vitamin A’s role in reproduction and development, drawing substantially on animal and genetic models. Normal biological necessity does not mean extra supplementation improves fertility. Forms and amounts matter; use your bottle’s approved label and seek individual advice.

NIH nutrient reference

The NIH Office of Dietary Supplements describes copper as a cofactor for enzymes involved in energy production, iron metabolism, connective-tissue synthesis and defence against oxidative damage. This establishes biological functions, not a fertility benefit from supplementation or from the finished SIRE formula.

Randomized human trial after surgery

In an 80-day placebo-controlled trial in men after varicocele surgery, the alpha-lipoic acid group had higher total and progressive sperm motility than the placebo group. This was a specific postoperative population receiving 600 mg daily. It does not establish effects for other men, pregnancy outcomes or SIRE’s 250 mg amount shown on the photographed bottle.